There are two basic game types in Rise of Immortals: team-based PvP and cooperative PvE. The PvE mode essentially warms you up to the more competitive PvP mode.

In PvP scenarios, two teams of players fight for total conquest in unique instanced battlefields. These games consist of 2-5 players per team and last anywhere between 35-50 minutes of play. Players who enter the queue without a preformed group will be matched based upon ranking and their persistent Prestige level.

The match begins with each team spawning at their respective base. There is a global delay timer in place before minions are spawned. During this time, players can take the time to establish lane tactics and purchase power-up items with starting gold points. Once the match has started, the main goal is to destroy the opposing team's base. Rise of Immortals offers multiple ways to accomplish this, with strategies determined by team dynamics and the particular scenario layout.

PvE scenarios offer a more casual, introductory player experience, pitting players against dynamic A.I. encounters in unique scenario environments. A player may choose to go solo or team-up with 2 other players to conquer PvE scenarios. Familiar gameplay elements such as lanes, minions, and inhibitors are presented in these PvE environments, and players will often need to maintain a defensive strategy while pushing against the enemy A.I.